If you visit New York and prefer spending money on other things than lodging then check-in at The Cosmopolitan Hotel in Tribeca. The location has the feeling of residential area with several nice restaurants around. A great place for the typical New Yorkish organic breakfast is Le Pain Quotidien located a block down the road.
If you fancy people watching and want to live where the action is then book a room at recently opened The Standard in Meatpacking district. The hotel probably has one of the best views in Manhattan but be prepared to shower overlooking the bedroom. Do not miss the gym on the 17th floor where the view gets even the laziest person motivated to stand on the treadmill. The hotel also hosts the restaurant The Standard Grill where you might dine next to Madonna.
